Steroid hormone biosynthesis in steroidogenic cells is regulated through trophic hormone
activation of protein kinase A (PKA) signaling pathways. However, many examples of the …

Steroid hormones are synthesized in steroidogenic cells of the adrenal, ovary, testis,
placenta and brain and are essential for normal reproductive function and bodily …

Cholesterol transport in the mitochondrial membrane, an essential step of steroid
biosynthesis, is mediated by a protein complex containing the steroidogenic acute …

The control of steroidogenesis via signal transduction mechanisms involving cAMP-
dependent and cAMP-independent mechanisms is reviewed. Several structurally unrelated …

In the gonads and adrenal glands, the transient increase in steroidogenesis after hormonal
stimulation requires modulation of steroidogenic acute regulatory protein (Star) expression …

Endoplasmic reticulum (ER) stress generally occurs in secretory cell types. It has been
reported that Leydig cells, which produce testosterone in response to human chorionic …

The elastic properties of extensible tissues such as arteries and skin are mainly due to the
presence of elastic fibers whose major component is the extracellular matrix protein elastin …

The steroidogenic acute regulatory (StAR) protein, a 30-kDa mitochondrial factor, is a key
regulator of steroid hormone biosynthesis, facilitating the transfer of cholesterol from the …

Nonylphenol (NP), a final metabolite of nonylphenol polyethoxylate, has been reported to
interfere with male reproduction. However, its mechanisms are not fully understood. In the …

Leydig cells are responsible for the synthesis and secretion of testosterone, processes
controlled by luteinizing hormone (LH). Binding of LH to a G protein-coupled receptor in the …