Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Highlights•Drug resistance towards chemotherapy and molecularly targeted therapies
remains a great challenge in cancer treatments.•Deubiquitinating enzymes (DUBs) regulate …

Abstract Ubiquitin-specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUBs)
in the ubiquitin-specific protease (USP) family. It is a key regulator of numerous cellular …

The ubiquitin-proteasome system (UPS) is an essential protein quality controller for
regulating protein homeostasis and autophagy. Ubiquitination is a protein modification …

PD-L1 is an important immune checkpoint protein that can bind to T cells' PD-1 receptor,
thereby promoting immune escape from tumors. In recent years, many researchers have …

Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-
damaging therapies than its HPV-negative counterpart. Here, we show that p16, the …

Objective This study aims to clarify the mechanical action of cyclin-dependent protein kinase
1 (CDK1) in the development of endometrial carcinoma (EMCA), which may be associated …

The midbody is an organelle that forms between the two daughter cells during cytokinesis. It
co-ordinates the abscission of the nascent daughter cells and is composed of a multitude of …

Every time a cell copies its DNA the genetic material is exposed to the acquisition of
mutations and genomic alterations that corrupt the information passed on to daughter cells …