Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
The human cortex comprises diverse cell types that emerge from an initially uniform
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …
Genetic regulation of vertebrate forebrain development by homeobox genes
Forebrain development in vertebrates is regulated by transcription factors encoded by
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …
[HTML][HTML] Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue
H Sakaguchi, T Kadoshima, M Soen, N Narii… - Nature …, 2015 - nature.com
The developing dorsomedial telencephalon includes the medial pallium, which goes on to
form the hippocampus. Generating a reliable source of human hippocampal tissue is an …
form the hippocampus. Generating a reliable source of human hippocampal tissue is an …
Tangential migration of glutamatergic neurons and cortical patterning during development: Lessons from Cajal‐Retzius cells
M Barber, A Pierani - Developmental neurobiology, 2016 - Wiley Online Library
Tangential migration is a mode of cell movement, which in the developing cerebral cortex, is
defined by displacement parallel to the ventricular surface and orthogonal to the radial glial …
defined by displacement parallel to the ventricular surface and orthogonal to the radial glial …
Transcription factors lhx1/5-1 and pitx are required for the maintenance and regeneration of serotonergic neurons in planarians
KW Currie, BJ Pearson - Development, 2013 - journals.biologists.com
In contrast to most adult organisms, freshwater planarians can regenerate any injured body
part, including their entire nervous system. This allows for the analysis of genes required for …
part, including their entire nervous system. This allows for the analysis of genes required for …
Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition
MX Moreau, Y Saillour, AW Cwetsch, A Pierani… - …, 2021 - journals.biologists.com
In the developing cerebral cortex, how progenitors that seemingly display limited diversity
end up producing a vast array of neurons remains a puzzling question. The prevailing model …
end up producing a vast array of neurons remains a puzzling question. The prevailing model …
hPSC modeling reveals that fate selection of cortical deep projection neurons occurs in the subplate
Cortical deep projection neurons (DPNs) are implicated in neurodevelopmental disorders.
Although recent findings emphasize post-mitotic programs in projection neuron fate …
Although recent findings emphasize post-mitotic programs in projection neuron fate …
Evolution and development of the mammalian cerebral cortex
Comparative developmental studies of the mammalian brain can identify key changes that
can generate the diverse structures and functions of the brain. We have studied how the …
can generate the diverse structures and functions of the brain. We have studied how the …
Combining information from genome-wide association and multi-tissue gene expression studies to elucidate factors underlying genetic variation for residual feed …
Background Genome-wide association studies (GWAS) are extensively used to identify
single nucleotide polymorphisms (SNP) underlying the genetic variation of complex traits …
single nucleotide polymorphisms (SNP) underlying the genetic variation of complex traits …
[HTML][HTML] Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons
Overexpression of mouse neurogenin (Neurog) 2 alone or in combination with mouse
Neurog2/1 in human embryonic stem cells (hESCs) and human induced pluripotent stem …
Neurog2/1 in human embryonic stem cells (hESCs) and human induced pluripotent stem …