An explosion in single-cell technologies has revealed a previously underappreciated
heterogeneity of cell types and novel cell-state associations with sex, disease, development …

Researchers view vast zeros in single-cell RNA-seq data differently: some regard zeros as
biological signals representing no or low gene expression, while others regard zeros as …

The scale and capabilities of single-cell RNA-sequencing methods have expanded rapidly
in recent years, enabling major discoveries and large-scale cell mapping efforts. However …

Understanding gene regulation and function requires a genome-wide method capable of
capturing both gene expression levels and isoform diversity at the single-cell level. Short …

The fundamental operative unit of a cancer is the genetically and epigenetically innovative
single cell. Whether proliferating or quiescent, in the primary tumour mass or disseminated …

Neurons exhibit a rich diversity of morphological phenotypes, electrophysiological
properties, and gene-expression patterns. Understanding how these different characteristics …

ABSTRACT A multitude of single-cell RNA sequencing methods have been developed in
recent years, with dramatic advances in scale and power, and enabling major discoveries …

Anxiety disorders are among the most prevalent psychiatric disorders, causing significant
suffering and disability. Relative to other psychiatric disorders, anxiety disorders tend to …

Although single-cell RNA sequencing can reliably detect large-scale transcriptional
programs, it is unclear whether it accurately captures the behavior of individual genes …

Neural crest cells migrate throughout the embryo, but how cells move in a directed and
collective manner has remained unclear. Here, we perform the first single-cell transcriptome …