Targets involved in the anti-cancer activity of quercetin in breast, colorectal and liver neoplasms

A Maugeri, A Calderaro, GT Patanè, M Navarra… - International Journal of …, 2023 - mdpi.com
Phytochemicals have long been effective partners in the fight against several diseases,
including cancer. Among these, flavonoids are valuable allies for both cancer prevention …

The role of OncoSnoRNAs and Ribosomal RNA 2'-O-methylation in Cancer

D Barros-Silva, J Klavert, G Jenster, C Jerónimo… - RNA biology, 2021 - Taylor & Francis
Ribosomes are essential nanomachines responsible for all protein production in cells.
Ribosome biogenesis and function are energy costly processes, they are tightly regulated to …

p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

P Bora, L Gahurova, T Mašek, A Hauserova… - Communications …, 2021 - nature.com
Successful specification of the two mouse blastocyst inner cell mass (ICM) lineages (the
primitive endoderm (PrE) and epiblast) is a prerequisite for continued development and …

[HTML][HTML] Mechanistic insights into hormesis induced by erythromycin in the marine alga Thalassiosira weissflogii

J Mo, R Lv, X Qin, X Wu, H Chen, N Yan, J Shi… - Ecotoxicology and …, 2023 - Elsevier
Erythromycin (ERY) is a typical macrolide antibiotic with large production and extensive use
on a global scale. Detection of ERY in both freshwaters and coaster seawaters, as well as …

Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development

KT Falcon, KEN Watt, S Dash, R Zhao… - Proceedings of the …, 2022 - National Acad Sciences
Ribosomal RNA (rRNA) transcription by RNA polymerase I (Pol I) is a critical rate-limiting
step in ribosome biogenesis, which is essential for cell survival. Despite its global function …

Comparative study of organoids from patient-derived normal and tumor colon and rectal tissue

A Costales-Carrera, A Fernández-Barral… - Cancers, 2020 - mdpi.com
Colon and rectal tumors, often referred to as colorectal cancer, show different gene
expression patterns in studies that analyze whole tissue biopsies containing a mix of tumor …

Carvacrol, Thymol, and Garlic Essential Oil Promote Skin Innate Immunity in Gilthead Seabream (Sparus aurata) Through the Multifactorial Modulation of the …

JP Firmino, L Fernández-Alacid… - Frontiers in …, 2021 - frontiersin.org
One of the main targets for the use of phytogenics in aquafeeds is the mucosal tissues as
they constitute a physical and biochemical shield against environmental and pathogenic …

[HTML][HTML] Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection

A Dangi, NR Natesh, I Husain, Z Ji, L Barisoni, J Kwun… - JCI insight, 2020 - ncbi.nlm.nih.gov
Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we
used a murine kidney transplantation model and single cell transcriptomics to dissect the …

N6-methyladenosine upregulates ribosome biogenesis in environmental carcinogenesis

T Zhao, D Sun, K Long, B Lemos, Q Zhang… - Science of The Total …, 2023 - Elsevier
Many trace metal pollutants in surface water, the atmosphere, and soil are carcinogenic, and
ribosome biogenesis plays an important role in the carcinogenicity of heavy metals …

m6A RNA methylation impacts fate choices during skin morphogenesis

L Xi, T Carroll, I Matos, JD Luo, L Polak, HA Pasolli… - Elife, 2020 - elifesciences.org
N6-methyladenosine is the most prominent RNA modification in mammals. Here, we study
mouse skin embryogenesis to tackle m6A's functions and physiological importance. We first …