Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

Traumatic brain injury (TBI) leads to multiple short-and long-term changes in neuronal
circuits that ultimately conclude with an imbalance of cortical excitation and inhibition …

This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …

The isolation and identification of the discrete plant cannabinoids in marijuana revived
interest in analyzing historical therapeutic claims made for cannabis in clinical case studies …

N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors.
NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or …

Background and Purpose—Activation of NMDA subtypes of glutamate receptors is
implicated in cell damage induced by ischemia as well as for the establishment of ischemic …

Inhibition of mTOR by rapamycin has been shown to suppress seizures in TSC/PTEN
genetic models. Rapamycin, when applied immediately before or after a neurological insult …

Abstract Lead (Pb 2+) is a ubiquitous environmental neurotoxicant that continues to threaten
public health on a global scale. Epidemiological studies have demonstrated detrimental …

Recurrent seizure activity has been shown to induce a variety of permanent structural
changes in the brain. Matrix metalloproteinases (MMPs) function to promote neuronal …