Poxviruses have evolved a wide array of mechanisms to evade the immune response, and
we provide an overview of the different immunomodulatory strategies. Poxviruses prevent …

▪ Abstract Ubiquitin regulates protein transport between membrane compartments by serving
as a sorting signal on protein cargo and by controlling the activity of trafficking machinery …

The PHD finger is a common structural motif found in all eukaryotic genomes. It is a Zn 2+-
binding domain and its closest structural relative is the RING domain. Many RING fingers …

Multivesicular endosomes are important as compartments for receptor downregulation and
as intermediates in the formation of secretory lysosomes. Work during the past year has …

Poxviruses and gamma-2 herpesviruses share the K3 family of viral immune evasion
proteins that inhibit the surface expression of glycoproteins such as major histocompatibility …

The phylum Nucleocytoviricota includes the largest and most complex viruses known. These
“giant viruses” have a long evolutionary history that dates back to the early diversification of …

The capacity for exquisite regulation of ubiquitylation provides eukaryotic cells with a means
to fine-tune both protein function and levels. This complex set of processes affects myriad …

Myxoma virus is a poxvirus naturally found in two American leporid (rabbit) species
(Sylvilagus brasiliensis and Sylvilagus bachmani) in which it causes an innocuous localised …

Ubiquitin (Ub)-protein conjugation represents a novel means of posttranscriptional
modification in a proteolysis-dependent or-independent manner. E3 Ub ligases play a key …

MHC class I molecules display peptides from endogenous and viral proteins for
immunosurveillance by cytotoxic T lymphocytes (CTL). The importance of the class I …