Both sensory neurons and immune cells, albeit at markedly different levels, express the
vanilloid (capsaicin) receptor, Transient Receptor Potential, Vanilloid-1 (TRPV1). Activation …

Transient receptor potential (TRP) channels are a superfamily of cation-specific permeable
channels primarily conducting Ca 2+ ions across various membranes of the cell. The …

Immunosuppression in cancer poses challenges for immunotherapy and highlights the
vulnerability of immunocompromised patients to viral infections. This study explored how …

Cancer is a global health challenge with rising incidence and mortality rates, posing
significant concerns. The World Health Organization reports cancer as a leading cause of …

ABSTRACT TRPV1 and TRPA1, are known to be functionally expressed in T cells, where
these two channels differentially regulate effector immune responses. Telmisartan (TM), an …

Melanoma, the most aggressive form of skin cancer with a high mutation rate, is the fifth most
common cancer among Caucasians. Despite advancements in treatments like immune …

In recent years, CAR-T cell therapy has revolutionized cancer immunotherapy, but there are
still major obstacles preventing its broader applications in treating solid tumors. Challenges …