Cancers of the head and neck that arise from habitual exposure to carcinogens have lower
cure rates than those that arise from infection with human papillomavirus (HPV), and …

Tumor cell growth and survival can often be impaired by inactivating a single oncogen–a
phenomenon that has been called as “oncogene addiction.” It is in such scenarios that …

Background Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN)
has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5 …

A disintegrin and metalloproteinase 17 (ADAM17) regulates key cellular processes
including proliferation and migration through the shedding of a diverse array of substrates …

Patients with squamous cell carcinoma of the head and neck (SCCHN) typically present with
locally advanced (LA) stage III or IV disease and are treated with combined-modality therapy …

Aberrations in the orderly function of the protein families of receptor tyrosine kinases (RTK)
rank among the most frequent oncogenic insults in virtually any type of cancer. The present …

Background Understanding molecular pathogenesis of head and neck squamous cell
carcinomas (HNSCC) has considerably improved in the last decades. As a result, novel …

Head and neck squamous cell carcinomas are rising in incidence worldwide, and despite
the advent of improved surgical and radiation techniques, a substantial proportion of …

The survival rate for patients with head and neck squamous cell cancer (HNSCC) is still
unsatisfactory despite advancements in the fields of surgery and radiochemotherapy. The …

In order to improve the prognosis for patients with head and neck squamous cell cancer
(HNSCC) the introduction of new therapeutic strategies is necessary. The concept of …