Gonad morphogenesis in vertebrates: divergent means to a convergent end
T DeFalco, B Capel - Annual Review of Cell and Developmental, 2009 - annualreviews.org
A critical element of successful sexual reproduction is the generation of sexually dimorphic
adult reproductive organs, the testis and ovary, which produce functional gametes …
adult reproductive organs, the testis and ovary, which produce functional gametes …
Development of the mammalian gonad: the fate of the supporting cell lineage
A McLaren - Bioessays, 1991 - Wiley Online Library
Sex determination in mammals is mediated via the supporting cell lineage in the fetal gonad.
In the very early stages of gonadal development, the fate of the supporting cell population is …
In the very early stages of gonadal development, the fate of the supporting cell population is …
Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes
S Dupont, A Krust, A Gansmuller, A Dierich… - …, 2000 - journals.biologists.com
The functions of estrogen receptors (ERs) in mouse ovary and genital tracts were
investigated by generating null mutants for ERα (ERαKO), ERβ (ERβKO) and both ERs …
investigated by generating null mutants for ERα (ERαKO), ERβ (ERβKO) and both ERs …
Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
Heterozygous mutations in SOX9 lead to a human dwarfism syndrome, Campomelic
dysplasia. Consistent with a role in sex determination, we find that Sox9 expression closely …
dysplasia. Consistent with a role in sex determination, we find that Sox9 expression closely …
Foxl2 is required for commitment to ovary differentiation
C Ottolenghi, S Omari, JE Garcia-Ortiz… - Human molecular …, 2005 - academic.oup.com
Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly
understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 …
understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 …
In situ analysis of fetal, prepuberal and adult XX ↔ XY chimaeric mouse testes: Sertoli cells are predominantly, but not exclusively, XY
SJ Palmer, PS Burgoyne - Development, 1991 - journals.biologists.com
The testes of fetal, prepuberal and adult XX↔ XY chimaeras were examined using in situ
hybridisation to identify the β-globin transgenic marker contained in one component of each …
hybridisation to identify the β-globin transgenic marker contained in one component of each …
[图书][B] Sex chromosomes and sex determination in vertebrates
AJ Solari - 2024 - books.google.com
The cloning of the SRY gene and the attainment of XX mice transgenic for the Sry gene
opened a new era in research on sex determination. This book surveys current knowledge …
opened a new era in research on sex determination. This book surveys current knowledge …
Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX↔ XY chimaeric mouse testes
The distribution of XX and XY cells in XX↔ XY chimaeric mouse testes was analysed by
enzyme marker analysis of separated testicular tissues and by in situ DNA marker analysis …
enzyme marker analysis of separated testicular tissues and by in situ DNA marker analysis …
SEX IN THE 90s: SRY and the Switch to the Male Pathway
B Capel - Annual review of physiology, 1998 - annualreviews.org
▪ Abstract In mammals the male sex determination switch is controlled by a single gene on
the Y chromosome, SRY. SRY encodes a protein with an HMG-like DNA-binding domain …
the Y chromosome, SRY. SRY encodes a protein with an HMG-like DNA-binding domain …
Regulation of sexual dimorphism in mammals
CM Haqq, PK Donahoe - Physiological Reviews, 1998 - journals.physiology.org
Haqq, Christopher M., and Patricia K. Donahoe. Regulation of Sexual Dimorphism in
Mammals. Physiol. Rev. 78: 1–33, 1998.—Sexual dimorphism in humans has been the …
Mammals. Physiol. Rev. 78: 1–33, 1998.—Sexual dimorphism in humans has been the …