Periplasmic chaperones: outer membrane biogenesis and envelope stress

AN Combs, TJ Silhavy - Annual Review of Microbiology, 2024 - annualreviews.org
Envelope biogenesis and homeostasis in gram-negative bacteria are exceptionally intricate
processes that require a multitude of periplasmic chaperones to ensure cellular survival …

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

S Okuda, DJ Sherman, TJ Silhavy, N Ruiz… - Nature Reviews …, 2016 - nature.com
Gram-negative bacteria have a double-membrane cellular envelope that enables them to
colonize harsh environments and prevents the entry of many clinically available antibiotics …

The bacterial cell envelope

TJ Silhavy, D Kahne, S Walker - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The bacteria cell envelope is a complex multilayered structure that serves to protect these
organisms from their unpredictable and often hostile environment. The cell envelopes of …

Outer membrane biogenesis

A Konovalova, DE Kahne… - Annual review of …, 2017 - annualreviews.org
The hallmark of gram-negative bacteria and organelles such as mitochondria and
chloroplasts is the presence of an outer membrane. In bacteria such as Escherichia coli, the …

Assembly and maintenance of lipids at the bacterial outer membrane

E Lundstedt, D Kahne, N Ruiz - Chemical reviews, 2020 - ACS Publications
The outer membrane of Gram-negative bacteria is essential for their survival in harsh
environments and provides intrinsic resistance to many antibiotics. This membrane is …

Outer membrane protein biogenesis in Gram-negative bacteria

SE Rollauer, MA Sooreshjani… - … Transactions of the …, 2015 - royalsocietypublishing.org
Gram-negative bacteria contain a double membrane which serves for both protection and for
providing nutrients for viability. The outermost of these membranes is called the outer …

Outer membrane protein assembly mediated by BAM-SurA complexes

KL Fenn, JE Horne, JA Crossley, N Böhringer… - Nature …, 2024 - nature.com
The outer membrane is a formidable barrier that protects Gram-negative bacteria against
environmental threats. Its integrity requires the correct folding and insertion of outer …

β-Barrel membrane protein assembly by the Bam complex

CL Hagan, TJ Silhavy, D Kahne - Annual review of biochemistry, 2011 - annualreviews.org
β-barrel membrane proteins perform important functions in the outer membranes (OMs) of
Gram-negative bacteria and of the mitochondria and chloroplasts of eukaryotes. The protein …

Reconstitution of outer membrane protein assembly from purified components

CL Hagan, S Kim, D Kahne - Science, 2010 - science.org
β-barrel membrane proteins in Gram-negative bacteria, mitochondria, and chloroplasts are
assembled by highly conserved multi-protein complexes. The mechanism by which these …

Microbial Peptidyl-Prolyl cis/trans Isomerases (PPIases): Virulence Factors and Potential Alternative Drug Targets

CM Ünal, M Steinert - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases
(PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at …