Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Induced pluripotent stem cell (iPSC) technology enabled the production of pluripotent stem
cell lines from somatic cells from a range of known genetic backgrounds. Their ability to …

SCN2A encodes NaV1. 2, an excitatory neuron voltage-gated sodium channel and a major
monogenic cause of neurodevelopmental disorders, including developmental and epileptic …

Astrocytes are essential for the formation and maintenance of neural networks. However, a
major technical challenge for investigating astrocyte function and disease-related …

Missense variants in SCN3A encoding the voltage-gated sodium (Na+) channel α subunit
Nav1. 3 are associated with SCN3A-related neurodevelopmental disorder (SCN3A-NDD), a …

The derivation of neuronal lineage cells from human induced pluripotent stem cells (hiPSCs)
marked a milestone in brain research. Since their first advent, protocols have been …

Human induced pluripotent stem cells (hiPSCs) derived into neurons offer a powerful in vitro
model to study cellular processes. One method to characterize functional network properties …

Understanding the complex interplay between gene expression and neuronal activity is
crucial for unraveling the molecular mechanisms underlying cognitive function and …

Induced pluripotent stem cell (iPSC)-derived neurons have been identified as a promising
model system to improve translation of preclinical neuroscience studies to the clinic. The use …

Neurodegenerative disorders, including Alzheimer's disease, pose a global social burden
strongly linked with aging populations. Despite extensive research efforts, the underlying …