Abstract The anticancer compound taxol (1.1. 1) was originally isolated in the late 1960's
from the bark of the Western Yew, Taxus brevifolia, and its structure was published in 1971 …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The chemotherapeutic drug Taxol is known to interact within a specific site on β-tubulin.
Although the general location of the site has been defined by photoaffinity labeling and …

This volume brings together all aspects of TAXOL® research, development, and clinical use.
It provides comprehensive knowledge of the compound and a perspective of the complex …

Tubulin targeting agents constitute an important class of anticancer drugs. By acting either
as microtubule stabilizers or destabilizers, they disrupt microtubule dynamics, thus inducing …

There is a cartoon by the New Yorker cartoonist Charles Barsotti that shows a man in a suit
and tie standing before a glass display case, looking with respectful awe at the single small …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is a trimer of
S1/S2 heterodimers with three receptor-binding domains (RBDs) at the S1 subunit for …

The first contribution of this book gives an overview on naturally occuring cycling
tetrapyrroles. The article describes the four classic tetrapyrrolic structures with their …

Recent research on the chemistry of natural products from the author's group that led to the
receipt of the ACS Ernest Guenther Award in the Chemistry of Natural Products is reviewed …

The important anticancer drug Taxol (paclitaxel, PTX) owes its unique activity to its ability to
bind to tubulin in a stoichiometric ratio and promote its assembly into microtubules. The …