What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?

JI Berger, AJ Billig, W Sedley, S Kumar… - Human brain …, 2024 - Wiley Online Library
The hippocampus and parahippocampal gyrus have been implicated as part of a tinnitus
network by a number of studies. These structures are usually considered in the context of a …

A Systematic Review on the Genetic Contribution to Tinnitus

P Perez-Carpena, JA Lopez-Escamez… - Journal of the …, 2024 - Springer
Purpose To assess the available evidence to support a genetic contribution and define the
role of common and rare variants in tinnitus. Methods After a systematic search and quality …

Genetic architecture distinguishes tinnitus from hearing loss

RE Clifford, AX Maihofer, C Chatzinakos… - Nature …, 2024 - nature.com
Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical
specialties. Previous GWAS indicated high genetic correlations between tinnitus and …

Treatment outcomes in tinnitus patients are associated with brain functional network: Evidence from connectome gradient and gene expression analysis

N Wu, M Xu, C Liu, Q Chen, JH Gao, Z Wang, H Lv - Neuroscience, 2024 - Elsevier
The neuroimaging mechanisms underlying differences in the outcomes of sound therapy for
tinnitus patients remain unclear. We hypothesize that abnormal hierarchical architecture is …

Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically audiogenic …

SM Díaz-Rodríguez, MJ Herrero-Turrión… - Frontiers in Molecular …, 2024 - frontiersin.org
Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven
neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy …

Rare deletions or large duplications contribute to genetic variation in patients with severe tinnitus and Meniere disease

A Escalera-Balsera, AM Parra-Perez… - Genes, 2023 - mdpi.com
Meniere disease (MD) is a debilitating disorder of the inner ear defined by sensorineural
hearing loss (SNHL) associated with episodes of vertigo and tinnitus. Severe tinnitus, which …

Comparison of GWAS results between de novo tinnitus and cancer treatment-related tinnitus suggests distinctive roles for genetic risk factors

M Shahbazi, HE Wheeler, GT Armstrong, RD Frisina… - Scientific Reports, 2024 - nature.com
Tinnitus is a common sensorineural complication that can occur de novo or after cancer
treatments involving cisplatin or radiotherapy. Considering the heterogeneous etiology and …

Identifying Health-Related Conditions Associated with Tinnitus in Young Adults

IS Bhatt, NJ Washnik, S Kingsbury, AK Deshpande… - Audiology …, 2023 - mdpi.com
Objective: The present study investigated the epidemic of tinnitus in college-aged young
adults. Our first objective was to identify health conditions associated with tinnitus in young …

Tinnitus Mechanisms and the Need for an Objective Electrophysiological Tinnitus Test. A Review.

E Fabrizio-Stover, DL Oliver, AL Burghard - Hearing Research, 2024 - Elsevier
Tinnitus, the perception of sound with no external auditory stimulus, is a complex,
multifaceted, and potentially devastating disorder. Despite recent advances in our …

DNA Methylation Patterns Associated with Tinnitus in Young Adults—A Pilot Study

IS Bhatt, JAR Garay, A Torkamani, R Dias - Journal of the Association for …, 2024 - Springer
Purpose Tinnitus, the perception of sound without any external sound source, is a prevalent
hearing health concern. Mounting evidence suggests that a confluence of genetic …