The management of primary central nervous system (PCNSL) is one of the most
controversial topics in neuro-oncology because of the complexity of the disease and the …

Nucleic acid (NA) therapeutics are a rapidly growing class of biomedicines with the ability to
manipulate gene expression in potent and specific manner, and with the enormous potential …

Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they
support vasculature functioning, participate in tissue regeneration, and regulate blood flow …

Simple Summary Primary central nervous system lymphoma is a rare and aggressive form of
non-Hodgkin lymphoma. While it is highly responsive to first-line chemo and radiation …

Highlights•Solid tumors represent the vast majority of newly diagnosed cancer, and yet only
50% of immuno-oncology trials are directed to them.•Several barriers limit efficacy of …

Highlights This EHA‐ESMO Clinical Practice Guideline provides key recommendations for
managing primary DLBCL of the CNS. The guideline covers clinical, imaging and …

APN/CD13 is expressed in a variety of cells/tissues and is therefore associated with diverse
physiological functions, including proliferation, differentiation, migration, angiogenesis …

Over the last decade research on cancer stem cells (CSC) significantly contributed to a
better understanding of tumor biology. Given their similarity to normal stem cells, ie self …

Contrast enhanced magnetic resonance imaging (CE-MRI) remains the imaging modality of
choice for initial workup, staging, and response assessment after therapy in patients with …

Background Gold nanospheres tagged with peptides containing iso DGR (iso Asp-Gly-Arg),
an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory …