Organophosphorus compounds (OPCs) are able to interact with various biological targets in
living organisms, including enzymes. The binding of OPCs to enzymes does not always lead …

Medicinal chemistry is facing new challenges in approaching precision medicine. Several
powerful new tools or improvements of already used tools are now available to medicinal …

A key aspect of adaptation to cold environments is the production of cold‐active enzymes by
psychrophilic organisms. These enzymes not only have high activity at low temperatures, but …

Cold environments characterised by diverse temperatures close to or below the water
freezing point dominate about 80% of the Earth's biosphere. One of the survival strategies …

Detailed study of conformational rearrangements and dynamics of proteins is central to our
understanding of their physiological functions and the loss of function. This review outlines …

Methods The partial bond length vdWV diameter (vdWDpb, nm) is applied for correlative
modeling of diameter or volume normalized fractional solubility (Log S), partition coefficient …

Trace amounts of “bio-metals” are essential for maintaining our life, but we have not yet fully
understood mechanisms of how they function in proteins, cells, organs, and bodies. The …