Intrinsically disordered proteins: an overview

R Trivedi, HA Nagarajaram - International journal of molecular sciences, 2022 - mdpi.com
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

LEAfing through literature: late embryogenesis abundant proteins coming of age—achievements and perspectives

IE Hernández-Sánchez, I Maruri-López… - Journal of …, 2022 - academic.oup.com
To deal with increasingly severe periods of dehydration related to global climate change, it
becomes increasingly important to understand the complex strategies many organisms have …

Biological soft matter: intrinsically disordered proteins in liquid–liquid phase separation and biomolecular condensates

AV Fonin, IA Antifeeva, IM Kuznetsova… - Essays in …, 2022 - portlandpress.com
The facts that many proteins with crucial biological functions do not have unique structures
and that many biological processes are compartmentalized into the liquid-like biomolecular …

Analytical theory for sequence-specific binary fuzzy complexes of charged intrinsically disordered proteins

AN Amin, YH Lin, S Das, HS Chan - The Journal of Physical …, 2020 - ACS Publications
Intrinsically disordered proteins (IDPs) are important for biological functions. In contrast to
folded proteins, molecular recognition among certain IDPs is “fuzzy” in that their binding …

Interfacial Tensions of Polyelectrolyte Multiphase Coacervation

J Wang, X Chen, EQ Chen, S Yang - Macromolecules, 2024 - ACS Publications
Interfacial tension is a crucial property for a charged polymer system undergoing liquid–
liquid phase separation as it governs the structure and morphology of condensate phases …

Multiphase Coacervation of Polyelectrolytes Driven by Asymmetry of Charged Sequence

X Chen, EQ Chen, S Yang - Macromolecules, 2022 - ACS Publications
The complex coacervation of oppositely charged polyelectrolytes is an important issue,
which is relevant to many biological and industrial applications. While various biomolecules …

Review of Carrier-Free Self-Assembly of Anticancer Nanodrugs

H Ji, W Wang, O Qiao, X Hao - ACS Applied Nano Materials, 2024 - ACS Publications
Nanodrugs represent a drug delivery form that brings hope for optimal drug release due to
their inherent properties. Special carrier materials give hydrophobic drugs excellent water …

Liquid-liquid phase separation in human diseases: Functions, mechanisms and treatments

T Yue, F Zhang, Y Wei, Z Wang - Nano Today, 2024 - Elsevier
Cells are separated into functional regions by non-membrane organelles and membrane-
enclosed organelles, ensuring that various cellular activities occur in a controlled manner in …

Disordered regions tune order in chromatin organization and function

S Shukla, P Agarwal, A Kumar - Biophysical Chemistry, 2022 - Elsevier
Intrinsically disordered proteins or hybrid proteins with ordered domains and disordered
regions (both collectively designated as IDP (R) s) defy the well-established structure …

[HTML][HTML] Molecular electrostatics and pKa shifts calculations with the Generalized Born model. A tutorial through examples with Bluues2

MA Soler, O Ozkilinc, Y Hunashal, P Giannozzi… - Computer Physics …, 2023 - Elsevier
Biomolecular electrostatics is of key importance for biological function and recognition. The
continuum electrostatic model based on the Poisson-Boltzmann (PB) equation has been …