Episodic memory relies on the hippocampus, a heterogeneous brain region with distinct
functions. Spatial representations in the dorsal hippocampus (dHPC) are crucial for …

The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in
executive and emotional functions. Neurophysiological studies have begun to unveil the …

Memory consolidation during sleep is thought to depend on the coordinated interplay
between cortical slow waves, thalamocortical sleep spindles and hippocampal ripples, but …

The ability to rapidly adapt to novel situations is essential for survival, and this flexibility is
impaired in many neuropsychiatric disorders. Thus, understanding whether and how novelty …

Learning-activated engram neurons play a critical role in memory recall. An untested
hypothesis is that these same neurons play an instructive role in offline memory …

Background: Poststroke cognitive impairments are common in stroke survivors, and pose a
high risk of incident dementia. However, the cause of these cognitive impairments is obscure …

Background: Normal aging is accompanied by cognitive deficiencies, affecting women and
men equally. Aging is the main risk factor for Alzheimer's disease (AD), with women having a …

Meta-analysis of genome-wide association study data has implicated PDE4B in the
pathogenesis of Alzheimer's disease (AD), the leading cause of senile dementia. PDE4B …

The hippocampus (HPC) and medial prefrontal cortex (mPFC) have well-established roles in
cognition, emotion, and sensory processing. In recent years, interests have shifted towards …

Sleep is a highly conserved state across the animal kingdom. However, sleep duration,
behavior and associated neural activity show great diversity across taxonomic groups, and …