Pluripotent stem cells for target organ developmental toxicity testing

X Wu, Y Chen, A Kreutz, B Silver… - Toxicological …, 2024 - academic.oup.com
Prenatal developmental toxicity research focuses on understanding the potential adverse
effects of environmental agents, drugs, and chemicals on the development of embryos and …

Development of a physiologically based toxicokinetic model for lead in pregnant women: The role of bone tissue in the maternal and fetal internal exposure

YA Daoud, C Tebby, R Beaudouin, C Brochot - Toxicology and Applied …, 2023 - Elsevier
Epidemiological studies have shown associations between prenatal exposure to lead (Pb)
and neurodevelopmental effects in young children. Prenatal exposure is generally …

Revolutionizing developmental neurotoxicity testing–A journey from animal models to advanced in vitro systems

L Smirnova, HT Hogberg, M Leist, T Hartung - ALTEX-Alternatives to …, 2024 - altex.org
Developmental neurotoxicity (DNT) testing has seen enormous progress over the last two
decades. Preceding even the publication of the animal-based OECD test guideline for DNT …

Une Approche quantitative de l'exposition fœtale au plomb: développement d'un modèle pharmacocinétique basé sur la physiologie de la grossesse (p-PBPK) et …

YA Daoud - 2024 - pastel.hal.science
Le plomb (Pb) est une neurotoxine très puissante, notamment pour les enfants. Une vaste
littérature épidémiologique documente les effets de l'exposition au Pb chez les jeunes …