The availability of the first molecular clone of the hepatitis C virus (HCV) genome allowed
the identification and biochemical characterization of two viral enzymes that are targets for …

The treatment of HCV infection has evolved at an extremely rapid pace over the past few
years. The development of direct-acting antiviral agents, which potently inhibit different …

Hepatitis C virus (HCV) infection is a global health problem that impacts approximately 180
million individuals. Of those initially infected with HCV approximately 80% will progress to …

Since the discovery of the human immunodeficiency virus (HIV) in 1983, dramatic progress
has been made in the development of novel antiviral drugs. The HIV epidemic fuelled the …

Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to
come because of the chronic nature of the infection, its high prevalence and the significant …

Genome replication is a crucial step in the life cycle of any virus. HCV is a positive strand
RNA virus and requires a set of nonstructural proteins (NS3, 4A, 4B, 5A, and 5B) as well as …

RNA-dependent RNA polymerases (RdRPs) play key roles in viral transcription and genome
replication, as well as epigenetic and post-transcriptional control of cellular gene …

Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent
RNA polymerase, termed 3D. These viruses also use a small protein primer, named VPg, to …

The hepatitis C virus (HCV) is a pandemic human pathogen posing a substantial health and
economic burden in both developing and developed countries. Controlling the spread of …

The use of halogens in therapeutics dates back to the earliest days of medicine when
seaweed was used as a source of iodine to treat goiters. The incorporation of halogens to …