Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …

Lipid droplets are dynamic intracellular lipid storage organelles that respond to the
physiological state of cells. In addition to controlling cell metabolism, they play a protective …

Lipid droplets are the intracellular sites for neutral lipid storage. They are critical for lipid
metabolism and energy homeostasis, and their dysfunction has been linked to many …

Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various
organelles including peroxisomes. Here, we show that the hereditary spastic paraplegia …

Hereditary spastic paraplegias (HSP) are a heterogeneous group of motor
neurodegenerative disorders that have the core clinical presentation of pyramidal syndrome …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

Lipids are essential components for life. Their various structural and physical properties
influence diverse cellular processes and, thereby, human health. Lipids are not genetically …

The hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurologic
disorders with the common feature of prominent lower-extremity spasticity, resulting from a …

Abstract Purpose of Review Hereditary spastic paraplegias are a genetically heterogeneous
group of neurological disorders. Patients present lower limb weakness and spasticity …

When the brain is in a pathological state, the content of lipid droplets (LDs), the lipid storage
organelles, is increased, particularly in glial cells, but rarely in neurons. The biology and …