In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …

To survive inhospitable environments, tumor cells are forced to remodel their signaling
pathways by altering transcription, translation, and post-translational modifications. This …

Although transcript levels have been traditionally used as a surrogate measure of gene
expression, it is increasingly recognized that the latter is extensively and dynamically …

Aggressive double-and triple-hit (DH/TH) diffuse large B-cell lymphomas (DLBCLs) feature
activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls …

The growing cost of medical care worldwide, particularly in oncology, has incentivized
researchers and physicians to repurpose clinically used drugs to alleviate the financial …

Protein synthesis can be segmented into distinct phases comprising mRNA translation
initiation, elongation, and termination. Translation initiation is a highly regulated and rate …

Breast cancer diagnosed within 10 years following childbirth is defined as postpartum breast
cancer (PPBC) and is highly metastatic. Interactions between immune cells and other …

Translation initiation is a critical facet of gene expression with important impacts that
underlie cellular responses to stresses and environmental cues. Its dysregulation in many …

We have previously shown that lipoma preferred partner (LPP) mediates TGFβ-induced
breast cancer cell migration and invasion. Herein, we demonstrate that diminished LPP …