Children differ from adults in many aspects of pharmacotherapy, including capabilities for
drug administration, medicine-related toxicity, and taste preferences. It is essential that …

Paediatric formulation design is complex as there is a need to understand the
developmental physiological changes that occur during childhood and their impact on the …

The aim of the present paper is to illustrate the impact that excipients may have on the
bioavailability of drugs and to review existing US-FDA, WHO and EMA regulatory guidelines …

The majority of the drugs currently used for the treatment of HIV infections (AIDS) belong to
either of the following three classes: nucleoside reverse transcriptase inhibitors (NRTIs) …

Nanotechnology has become a key tool to overcome the main (bio) pharmaceutical
drawbacks of drugs and to enable their passive or active targeting to specific cells and …

In children aged≤ 4 years, the relative bioavailability of lamivudine oral solution was 37%
lower than that of a tablet formulation. An open‐label, four‐way crossover study was …

Background Coformulated bictegravir, emtricitabine, and tenofovir alafenamide is a single-
tablet regimen and was efficacious and well tolerated in children and adolescents with HIV …

2283-2296. 8. Brown TT, Cole SR, Li X, et al. Antiretroviral therapy and the prevalence and
incidence of diabetes mellitus in the multicenter AIDS cohort study. Arch Intern Med. 2005; …

The bioequivalence of formulations is usually evaluated in healthy adult volunteers. In our
study in 19 HIV–1–infected Ugandan children (1.8–4 years of age, weight 12 to< 15 kg) …

Nevirapine, a component of antiretroviral therapy (ART) in resource-limited settings, known
for auto-induction of metabolism, is initiated at half therapeutic dose until day 14 ('lead-in …