Over the past decades, increasing evidence has indicated that mechanical loads can
regulate the morphogenesis, proliferation, migration, and apoptosis of living cells …

With the development of oncology and bioanalytical chemistry, liquid biopsy emerges as
their fruit and manages to bring perspective chance of healthcare. To date, several typical …

Mechanical forces drive critical cellular processes that are reflected in mechanical
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …

Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in
the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore …

Podosomes are integrin-mediated cell adhesion units involved in many cellular and
physiological processes. Integrins likely transmit tensions critical for podosome functions …

DNA is a versatile biomaterial with well-defined mechanical and biochemical properties. It
has been broadly adopted to synthesize tension sensors that calibrate and visualize cellular …

Podosomes and invadopodia, collectively termed invadosomes, are adhesive and
degradative membrane structures formed in many types of cells and are well known for …

Invadopodia are involved in cancer invasion by generating mechanical forces and secreting
proteolytic enzymes. It is hypothesized that physical forces applied to integrin, especially …

Single-molecule force measurement techniques provide unique opportunities to investigate
simple molecular interactions and complicated force-induced cell responses. This has …

Nucleases are a group of enzymes that cleave the phosphodiester bonds in nucleic acids.
As such, nucleases act as biological scissors that exhibit a plethora of fundamental roles, in …