The intricate patterning processes that establish the complex vascular system during
development depend on a combination of intrinsic pre-patterning and extrinsic responses to …

Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic
system and provide an organism throughout its life with all blood cell types. Several tissues …

Myocyte loss in the ischemically injured mammalian heart often leads to irreversible deficits
in cardiac function. To identify a source of stem cells capable of restoring damaged cardiac …

Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate
a role for blood vessels as a source of developmental signals during pancreatic …

Tube and lumen formation are essential steps in forming a functional vasculature. Despite
their significance, our understanding of these processes remains limited, especially at the …

Branching morphogenesis in the mammalian lung and Drosophila trachea relies on the
precise localization of secreted modulators of epithelial growth to select branch sites and …

Recent evidence indicates that acquisition of artery or vein identity during vascular
development is governed, in part, by genetic mechanisms. The artery-specific expression of …

Blood cells are constantly produced in the bone marrow (BM) of adult mammals. This
constant turnover ultimately depends on a rare population of progenitors that displays self …

Among the three embryonic germ layers, the mesoderm is a major source of the
mesenchymal precursors giving rise to skeletal and connective tissues, but these precursors …

The zebrafish has emerged as an excellent vertebrate model system for studying blood and
lymphatic vascular development. The small size, external and rapid development, and …