Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study …

Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

It has long been recognized that the mammalian gut microbiota has a role in the
development and activation of the host immune system. Much less is known on how host …

Immunoglobulin A (IgA) is the most prevalent antibody at mucosal sites, and has an
important role in defense by preventing invasion of pathogens. Traditionally, IgA has been …

Human immunodeficiency virus (HIV) disease is associated with dysregulation and
dysfunction involving all major lymphocyte populations, including B cells. Such perturbations …

Immunodeficient mice engrafted with human cells and tissues have provided an exciting
alternative to in vitro studies with human tissues and nonhuman primates for the study of …

In rare cases, B cells can supply HIV-1-infected individuals with unconventional antibodies
equipped to neutralize the wide diversity of viral variants. Innovations in single-cell cloning …

The development of safe and effective combination antiretroviral therapies for human
immunodeficiency virus (HIV) infection over the past several decades has significantly …

Highlights•BLT humanized mice are valuable models for the study of HIV infection.•BLT mice
recapitulate important aspects of human immunity, including T cell immunity.•Various …

Lymphocytes have always been among the prime targets in gene therapy, even more so
since chimeric antigen receptor (CAR) T cells have reached the clinic. However, other gene …