[HTML][HTML] Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells
L Iovino, ME Tremblay, L Civiero - Journal of pharmacological sciences, 2020 - Elsevier
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
transmission efficiency depends on the correct functionality and expression of a plethora of …
transmission efficiency depends on the correct functionality and expression of a plethora of …
Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches
JF Poulin, Z Gaertner, OA Moreno-Ramos… - Trends in …, 2020 - cell.com
Dysfunctional dopamine (DA) signaling has been associated with a broad spectrum of
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …
VTA glutamate neuron activity drives positive reinforcement absent dopamine co-release
Like ventral tegmental area (VTA) dopamine (DA) neurons, VTA glutamate neuron activity
can support positive reinforcement. However, a subset of VTA neurons co-release DA and …
can support positive reinforcement. However, a subset of VTA neurons co-release DA and …
Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia
Dopamine (DA) and glutamate neurotransmission are strongly implicated in schizophrenia
pathophysiology. While most studies focus on contributions of neurons that release only DA …
pathophysiology. While most studies focus on contributions of neurons that release only DA …
Parkinson's disease-associated, sex-specific changes in DNA methylation at PARK7 (DJ-1), SLC17A6 (VGLUT2), PTPRN2 (IA-2β), and NR4A2 (NURR1) in cortical …
J Kochmanski, NC Kuhn, AI Bernstein - npj Parkinson's Disease, 2022 - nature.com
Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing,
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …
[HTML][HTML] Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease
SL Nickels, J Modamio, B Mendes-Pinheiro… - Stem Cell Research, 2020 - Elsevier
The study of human midbrain development and midbrain related diseases, like Parkinson's
disease (PD), is limited by deficiencies in the currently available and validated laboratory …
disease (PD), is limited by deficiencies in the currently available and validated laboratory …
[HTML][HTML] Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology
As the ability to capture single-cell expression profiles has grown in recent years,
neuroscientists studying a wide gamut of brain regions have discovered remarkable …
neuroscientists studying a wide gamut of brain regions have discovered remarkable …
Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins
Dopamine (DA) neurons in the ventral tier of the substantia nigra pars compacta (SNc)
degenerate prominently in Parkinson's disease, while those in the dorsal tier are relatively …
degenerate prominently in Parkinson's disease, while those in the dorsal tier are relatively …
Dopamine neurons that cotransmit glutamate, from synapses to circuits to behavior
Discovered just over 20 years ago, dopamine neurons have the ability to cotransmit both
dopamine and glutamate. Yet, the functional roles of dopamine neuron glutamate …
dopamine and glutamate. Yet, the functional roles of dopamine neuron glutamate …
Roles of dopamine and glutamate co‐release in the nucleus accumbens in mediating the actions of drugs of abuse
Projections of ventral tegmental area dopamine (DA) neurons to the medial shell of the
nucleus accumbens have been increasingly implicated as integral to the behavioral and …
nucleus accumbens have been increasingly implicated as integral to the behavioral and …