Mounting evidence indicates that inflammatory cytokines contribute to the development of
depression in both medically ill and medically healthy individuals. Cytokines are important …

The past decades of biomedical research have yielded massive evidence for the
contribution of the microbiome in the development of a variety of chronic human diseases …

The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known
as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high …

Abstract The NLRP3-IL-1β pathway plays an important role in adipose tissue (AT)-induced
inflammation and the development of obesity-associated comorbidities. We aimed to …

Endoplasmic reticulum (ER)-associated degradation (ERAD) represents a principle quality
control mechanism to clear misfolded proteins in the ER; however, its physiological …

Inflammasome activation initiates the development of many inflammatory diseases,
including obesity and type 2 diabetes. Therefore, agents that target discrete activation steps …

Tubulointerstitial inflammation plays a key role in the development of diabetic nephropathy
(DN). Cytokines in the IL-1 family are the key pro-inflammatory cytokines of tubulointerstitial …

Suppressor/Enhancer of Lin-12-like (Sel1L) is an adaptor protein for the E3 ligase
hydroxymethylglutaryl reductase degradation protein 1 (Hrd1) involved in endoplasmic …

Summary Interleukin-18 (IL-18) is activated by Caspase-1 in inflammasome complexes and
has anti-obesity effects; however, it is not known which inflammasome regulates this …

Obesity increases the risk of type 2 diabetes through the induction of insulin resistance. The
mechanism of insulin resistance has been extensively investigated for more than 60 years …