In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Abstract The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in
early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has …

Developing functional organs from stem cells remains a challenging goal in regenerative
medicine. Existing methodologies, such as tissue engineering, bioprinting, and organoids …

The placenta sustains embryonic development and is critical for a successful pregnancy
outcome. It provides the site of exchange between the mother and the embryo, has …

The use of stem cells to model the early human embryo promises to transform our
understanding of developmental biology and human reproduction. In this review, we present …

The advent of novel 2D and 3D models for human development, including trophoblast stem
cells and blastoids, has expanded opportunities for investigating early developmental …

In recent years, the pursuit of inducing the trophoblast stem cell (TSC) state has gained
prominence as a compelling research objective, illuminating the establishment of the …

Basement membranes (BMs) are sheet-like structures of extracellular matrix (ECM) that
provide structural support for many tissues and play a central role in signaling. They are key …

Anterior-posterior axis formation regulated by the distal visceral endoderm (DVE) and
anterior visceral endoderm (AVE) is essential for peri-implantation embryogenesis …

The advent of novel 2D and 3D models for human development, including trophoblast stem
cells, gastruloids, and blastoids, has significantly expanded opportunities for investigating …