Natural products containing eight-membered carbocycles constitute a class of structurally
intriguing and biologically important molecules such as the famous diterpenes taxol and …

Polyketides represent an important class of natural products, renowned for their intricate
structures and diverse biological activities. In contrast to common fatty acids, polyketides …

Acetonaphthones, which bear an alkenyl group tethered to its C1 carbon atom via an
oxygen atom, were found to undergo an enantioselective intramolecular ortho …

The first enantioselective total synthesis of (+)-lucidumone is described through a 13-step
synthetic pathway (longest linear sequence). The key steps involve the formation of a …

Bridged medium-sized bicyclo [mn 2] ring systems are common in natural products and
potent pharmaceuticals, and pose a great synthetic challenge. Chemistry for making bicyclo …

A new synthetic strategy that forms a seven-membered carbocycle using an anionic 8π
electrocyclic reaction facilitated the first total synthesis of the 6, 11-epoxyisodaucane natural …

The Diels–Alder reaction has long been established as an extremely useful procedure in the
toolbox of natural product chemists. It tolerates a wide spectrum of building blocks of …

We report biosynthetic pathways that can synthesize and transform conjugated octaenes
and nonaenes to complex natural products. The biosynthesis of (−)-PF1018 involves an …

Nature has been recognized for her super capability of constructing complex molecules with
remarkable efficiency and elegancy. Among nature's versatile synthetic toolkits, Diels–Alder …

Bridged bicyclo [mn 2] ring systems (m> 2, n≥ 2) are important structural scaffolds, which
are widely found in diverse families of natural products. Such natural products are attracting …