Radiation therapy has curative or palliative potential in roughly half of all incident solid
tumours, and offers organ and function preservation in most cases. Unfortunately, early and …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by
promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 …

Of the various types of DNA damage that can occur within the mammalian cell, the DNA
double strand break (DSB) is perhaps the most dangerous. DSBs are typically induced by …

Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may
contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced …

In the past decade, CHK2 has emerged as an important multifunctional player in the DNA-
damage response signalling pathway. Parallel studies of the human CHEK2 gene have also …

Protein ubiquitylation has emerged as an important regulatory mechanism that impacts
almost every aspect of the DNA damage response. In this review, we discuss how DNA …

Polyploidy is much rarer in animals than in plants but it is not known why. The outcome of
combining two genomes in vertebrates remains unpredictable, especially because …

Abstract Purpose: Following cytotoxic therapy, 70% of patients with human papillomavirus
(HPV)-positive oropharyngeal head and neck squamous cell carcinoma (HNSCC) are alive …

DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result
in cell death or genomic instability. DSB repair is usually facilitated by the classical non …