Combination of antimalarial and CNS drugs with antineoplastic agents in MCF-7 breast and HT-29 colon cancer cells: Biosafety evaluation and mechanism of action
Drug combination and drug repurposing are two strategies that allow to find novel
oncological therapies, in a faster and more economical process. In our previous studies, we …
oncological therapies, in a faster and more economical process. In our previous studies, we …
Pitavastatin and ivermectin enhance the efficacy of paclitaxel in chemoresistant high-grade serous carcinoma
Simple Summary The main challenge in high-grade serous carcinoma management is to
unveil therapeutic approaches to overcome chemoresistance. Drug combinations and …
unveil therapeutic approaches to overcome chemoresistance. Drug combinations and …
The peptide-drug conjugate TH1902: a new sortilin receptor-mediated cancer therapeutic against ovarian and endometrial cancers
JC Currie, M Demeule, C Charfi, A Zgheib, A Larocque… - Cancers, 2022 - mdpi.com
Simple Summary Tumor heterogeneity, drug resistance, and systemic toxicity are major
concerns throughout treatments of gynecological cancers. Off-target toxicity is also a …
concerns throughout treatments of gynecological cancers. Off-target toxicity is also a …
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer
Background Platinum resistance is the primary cause of poor survival in ovarian cancer (OC)
patients. Targeted therapies and biomarkers of chemoresistance are critical for the treatment …
patients. Targeted therapies and biomarkers of chemoresistance are critical for the treatment …
Acquisition of paclitaxel resistance modulates the biological traits of gastric cancer AGS cells and facilitates epithelial to mesenchymal transition and angiogenesis
A Niapour, N Seyedasli - Naunyn-Schmiedeberg's Archives of …, 2022 - Springer
Purpose This study aims to develop a paclitaxel (PTX)-resistant gastric cancer AGS cells
(AGS-R) and evaluate the mechanisms of drug resistance. Methods AGS cells were …
(AGS-R) and evaluate the mechanisms of drug resistance. Methods AGS cells were …
Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer
L Li, L Yang, L Liu, F Liu, AH Li, Y Zhu, H Wen… - Acta Pharmacologica …, 2024 - nature.com
Paclitaxel resistance is associated with a poor prognosis in non-small cell lung cancer
(NSCLC) patients, and currently, there is no promising drug for paclitaxel resistance. In this …
(NSCLC) patients, and currently, there is no promising drug for paclitaxel resistance. In this …
[HTML][HTML] Metformin Impairs Linsitinib Anti-Tumor Effect on Ovarian Cancer Cell Lines
DL Almeida-Nunes, JPN Silva, M Nunes… - International Journal of …, 2024 - mdpi.com
Ovarian cancer (OC) remains one of the leading causes of cancer-related mortality among
women. Targeting the insulin-like growth factor 1 (IGF-1) signaling pathway has emerged as …
women. Targeting the insulin-like growth factor 1 (IGF-1) signaling pathway has emerged as …
Deguelin Restores Paclitaxel Sensitivity in Paclitaxel-Resistant Ovarian Cancer Cells via Inhibition of the EGFR Signaling Pathway
S Bae, S Bae, HS Kim, YJ Lim, G Kim… - Cancer Management …, 2024 - Taylor & Francis
Background Ovarian cancer is one of women's malignancies with the highest mortality
among gynecological cancers. Paclitaxel is used in first-line ovarian cancer chemotherapy …
among gynecological cancers. Paclitaxel is used in first-line ovarian cancer chemotherapy …
[HTML][HTML] Cyclin dependent kinase 14 as a paclitaxel-resistant marker regulated by the TGF-β signaling pathway in human ovarian cancer
W Guan, J Yuan, X Li, X Gao, F Wang, H Liu… - Journal of …, 2023 - ncbi.nlm.nih.gov
Abstract Cyclin dependent kinase 14 (CDK14) plays a central role in the control of cell
proliferation and cell cycle progression. However, the specific function and regulatory …
proliferation and cell cycle progression. However, the specific function and regulatory …
[HTML][HTML] Ivermectin Strengthens Paclitaxel Effectiveness in High-Grade Serous Carcinoma in 3D Cell Cultures
M Nunes, S Ricardo - Pharmaceuticals, 2024 - mdpi.com
Background: Chemoresistance is a major obstacle in high-grade serous carcinoma (HGSC)
treatment. Although many patients initially respond to chemotherapy, the majority of them …
treatment. Although many patients initially respond to chemotherapy, the majority of them …