Photodynamic therapy for cancer: Mechanisms, photosensitizers, nanocarriers, and clinical studies

W Zhao, L Wang, M Zhang, Z Liu, C Wu, X Pan… - MedComm, 2024 - Wiley Online Library
Photodynamic therapy (PDT) is a temporally and spatially precisely controllable,
noninvasive, and potentially highly efficient method of phototherapy. The three components …

Carrier-free nanodrugs: from bench to bedside

F Fang, X Chen - ACS nano, 2024 - ACS Publications
Carrier-free nanodrugs with extraordinary active pharmaceutical ingredient (API) loading
(even 100%), avoidable carrier-induced toxicity, and simple synthetic procedures are …

Lipid droplet targeting type I photosensitizer for ferroptosis via lipid peroxidation accumulation

T Xiong, Y Chen, Q Peng, S Lu, S Long, M Li… - Advanced …, 2024 - Wiley Online Library
As an iron‐dependent lipid peroxidation (LPO) mediated cell death pathway, ferroptosis
offers promises for anti‐tumor treatment. Photodynamic therapy (PDT) is an ideal way to …

Near‐Infrared Chemiluminescence Imaging of Chemotherapy‐Induced Peripheral Neuropathy

J Liu, J Huang, X Wei, P Cheng, K Pu - Advanced Materials, 2024 - Wiley Online Library
Chemotherapy‐induced peripheral neuropathy (CIPN) has a high prevalence but is poorly
managed for cancer patients due to the lack of reliable and sensitive diagnostic techniques …

Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium (III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and …

J Kasparkova, A Hernández-García… - Journal of Medicinal …, 2023 - ACS Publications
A second-generation series of biscyclometalated 2-(5-aryl-thienyl)-benzimidazole and-
benzothiazole Ir (III) dppz complexes [Ir (C^ N) 2 (dppz)]+, Ir1–Ir4, were rationally designed …

[HTML][HTML] Synergization of an endoplasmic reticulum-targeted iridium (III) photosensitizer with PD-L1 inhibitor for oral squamous cell carcinoma immunotherapy

JY Zhou, QH Shen, XJ Hong, WY Zhang, Q Su… - Chemical Engineering …, 2023 - Elsevier
Inefficient activation of tumor immunogenicity and sustained immunosuppressive
microenvironments severely impede the clinical application of photodynamic therapy (PDT) …

Supramolecular artificial Nano-AUTACs enable tumor-specific metabolism protein degradation for synergistic immunotherapy

Y Wang, L Yang, C Yan, Y Du, T Li, W Yang, L Lei… - Science …, 2024 - science.org
Autophagy-targeting chimera (AUTAC) has emerged as a powerful modality that can
selectively degrade tumor-related pathogenic proteins, but its low bioavailability and …

Ir (III) Half-Sandwich Photosensitizers with a π-Expansive Ligand for Efficient Anticancer Photodynamic Therapy

C Gonzalo-Navarro, E Zafon, JA Organero… - Journal of Medicinal …, 2024 - ACS Publications
One approach to reduce the side effects of chemotherapy in cancer treatment is
photodynamic therapy (PDT), which allows spatiotemporal control of the cytotoxicity. We …

A Photoactivatable Self-Assembled Nanoagonist for Synergistic Therapy against Pancreatic Ductal Adenocarcinoma

X Xu, T Li, T Yang, F Liu, Z Guo, H Wu, Y Tang… - Nano Letters, 2024 - ACS Publications
Immunotherapy has revolutionized the cancer treatment paradigm, yet efficient
immunotherapeutic responses against immune-cold/desert cancers remain challenging …

Multimetallic transition metal complexes: Luminescent probes for biomolecule sensing, ion detection, imaging and therapeutic application

B Das, P Gupta - Coordination Chemistry Reviews, 2024 - Elsevier
In the past decade, luminescent multimetallic transition metal complexes have become
indispensable tools in biology. They enable versatile applications, detecting biomolecules …