Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals
Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …
Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design
As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …
efficient strategies for their property improvement become increasingly important to global …
Recent advances in co-amorphous drug formulations
Co-amorphous drug delivery systems have recently gained considerable interest in the
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
Co-amorphous drug formulations in numbers: Recent advances in co-amorphous drug formulations with focus on co-formability, molar ratio, preparation methods …
Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …
or more (initially crystalline) low molecular weight components that form a homogeneous …
Co-amorphous solid dispersions for solubility and absorption improvement of drugs: Composition, preparation, characterization and formulations for oral delivery
The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …
However, due to thermodynamic instability and recrystallization tendencies during …
[图书][B] Polymorphism in the Pharmaceutical Industry: Solid Form and Drug Development
R Hilfiker, M Von Raumer - 2019 - books.google.com
" Polymorphism in the Pharmaceutical Industry-Solid Form and Drug Development"
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …
highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus …
[HTML][HTML] Advances in coamorphous drug delivery systems
Q Shi, SM Moinuddin, T Cai - Acta pharmaceutica sinica B, 2019 - Elsevier
In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …
Amino acids as co-amorphous stabilizers for poorly water soluble drugs–Part 1: Preparation, stability and dissolution enhancement
K Löbmann, H Grohganz, R Laitinen, C Strachan… - European journal of …, 2013 - Elsevier
Poor aqueous solubility of an active pharmaceutical ingredient (API) is one of the most
pressing problems in pharmaceutical research and development because up to 90% of new …
pressing problems in pharmaceutical research and development because up to 90% of new …
Co amorphous systems: A product development perspective
Solubility is one of the major problems associated with most of the new chemical entities that
can be reasonably addressed by drug amorphization. However, being a high-energy form, it …
can be reasonably addressed by drug amorphization. However, being a high-energy form, it …
Co-amorphous systems for the delivery of poorly water-soluble drugs: Recent advances and an update
J Han, Y Wei, Y Lu, R Wang, J Zhang… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction Most new drug candidates under development are poorly water-soluble, which
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …