Neurotoxicology is the study of adverse effects on the structure or function of the developing
or mature adult nervous system following exposure to chemical, biological, or physical …

Human induced pluripotent stem cell (iPSC)-derived neurons are of interest for studying
neurological disease mechanisms, developing potential therapies and deepening our …

Developmentally neurotoxic chemicals are a diverse set of substances that have the
potential to interfere with the normal development of the nervous system, which, if perturbed …

In vitro microelectrode array (MEA) assessment using human induced pluripotent stem cell
(iPSC)-derived neurons holds promise as a method of seizure and toxicity evaluation …

The currently accepted methods for neurotoxicity (NT) testing rely on animal studies.
However, high costs and low testing throughput hinder their application for large numbers of …

Recent advances in molecular and cellular engineering, such as human cell
reprogramming, genome editing, and patient-specific organoids, have provided …

Proper brain development is based on the orchestration of key neurodevelopmental
processes, including the formation and function of neural networks. If at least one key …

In situ physiological signals of in vitro neural disease models are essential for studying
pathogenesis and drug screening. Currently, an increasing number of in vitro neural disease …

Human pluripotent stem cell (hPSC)-derived neural cultures have attracted interest for
modeling epilepsy and seizure-like activity in vitro. Clinical and experimental evidence have …

Neuropathology is often mediated by interactions between neurons and glia that cannot be
modeled by monocultures. However, cocultures are difficult to use and analyze for high …