Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the
mucosal surfaces of the host nasopharynx and upper airway. Through a combination of …

Streptococcus pneumoniae is a major pathogen of humans, causing diseases such as
pneumonia and meningitis. The organism produces several virulence factors that are …

Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential
candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key …

The cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins that
are produced by more than 20 species from the genera Clostridium, Streptococcus, Listeria …

Streptococcus pneumoniae (the pneumoccus) is the leading cause of otitis media,
community-acquired pneumonia, and bacterial meningitis. The success of the …

The bacterial toxin pneumolysin is released as a soluble monomer that kills target cells by
assembling into large oligomeric rings and forming pores in cholesterol-containing …

Streptococcus pneumoniae is an opportunistic pathogen responsible for widespread illness
and is a major global health issue for children, the elderly, and the immunocompromised …

Diseases caused by Streptococcus pneumoniae include pneumonia, septicaemia and
meningitis. All these are associated with high morbidity and mortality. The pneumococcus …

Mice were infected intranasally with a serotype 2 pneumococcus, a pneumolysin-negative
derivative (PLN-A), or an autolysin-negative derivative (AL-2). Numbers of wild type …

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its
potential role in inflammation. However, most pieces of evidence are sparse and …