Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

The inhalation of cigarette smoke triggers a marked cellular influx in the lung, and this
inflammation is believed to play a central role in the development of smoke-related lung …

Abstract Objective Interleukin (IL)-17 plays an important role in the pathogenesis of asthma.
We investigated the association between single-nucleotide polymorphism (SNP) of IL-17 …

Rationale: Genes in the interleukin (IL)-4/IL-13/IL-4Rα pathway have been shown to be
associated with asthma and related phenotypes in some populations, but not in others …

5. Pascual M, Davila I, Isidoro-Garcia M, Lorente F. Epigenetic aspects of the allergic
diseases. Front Biosci (Schol Ed) 2010; 2: 815-24. 6. Jabara HH, Fu SM, Geha RS, Vercelli …

BACKGROUND: IL4R, the gene encoding the α chain of the IL-4 and IL-13 receptors, has
received extensive attention as a candidate gene for asthma risk. However, the results from …

Background Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. T-helper
(Th) 2 cytokines seems to have major roles behind the scene of unpleasant symptoms …

Abstract Background Interleukin 4 (IL4) is a key cytokine that regulates the inflammatory
cascade in bronchial asthma. We investigated the association between the IL4 and IL4R …

Background: Previous results demonstrated that sensitization to specific olive pollen
allergens could be related with a different clinical pattern (asthma and/or rhinitis), and that …

Background Interleukin-4 (IL4) is one of the most important cytokines involved in a variety of
allergic disorders, particularly, asthma. A number of genetic epidemiological studies have …