Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

The adaptive response of connective tissue to loading requires increased synthesis and
turnover of matrix proteins, with special emphasis on collagen. Collagen formation and …

Glaucoma is one of the most common neurodegenerative diseases. Despite this, the earliest
stages of this complex disease are still unclear. This study was specifically designed to …

Background Achilles tendinopathy is a common overuse injury, especially among athletes
involved in activities that include running and jumping. Often an initial period of rest from the …

This article is a summary of a lecture on cellular mechanotransduction that was presented at
a symposium on “Cardiac Mechano-Electric Feedback and Arrhythmias” that convened at …

Tissue mechanics provide an important context for tissue growth, maintenance and function.
On the level of organs, external mechanical forces largely influence the control of tissue …

Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …

Pelvic organ prolapse (POP) is a multifactorial connective tissue disorder caused by
damage to the supportive structures of the pelvic floor, leading to the descent of pelvic …

Disruption to proteins within the myofibre after a single bout of unaccustomed eccentric
exercise is hypothesized to induce delayed onset of muscle soreness and to be associated …

Tenascin-C is an adhesion modulatory extracellular matrix molecule that is highly expressed
in the microenvironment of most solid tumors. High tenascin-C expression reduces the …