How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis

LFZ Batista, B Kaina, R Meneghini… - … Research/Reviews in …, 2009 - Elsevier
Mammalian cells treated with ultraviolet (UV) light provide one of the best-known
experimental systems for depicting the biological consequences of DNA damage. UV …

[PDF][PDF] Recombinant protein therapeutics from CHO cells-20 years and counting

KP Jayapal, KF Wlaschin, W Hu… - Chemical engineering …, 2007 - researchgate.net
The CHO cell is at its height of technological prominence thanks to its adaptability to various
culture conditions and plasticity in the context of genetic alterations. With further research …

Dielectric model for Chinese hamster ovary cells obtained by dielectrophoresis cytometry

E Salimi, K Braasch, M Butler, DJ Thomson… - …, 2016 - pubs.aip.org
We present a dielectric model and its parameters for Chinese hamster ovary (CHO) cells
based on a double-shell structure which includes the cell membrane, cytoplasm, nuclear …

p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal

LFZ Batista, WP Roos, B Kaina, CFM Menck - Molecular Cancer Research, 2009 - AACR
The p53 protein is a key regulator of cell responses to DNA damage, and it has been shown
that it sensitizes glioma cells to the alkylating agent temozolomide by up-regulating the …

Extreme tolerance and developmental buffering of UV‐C induced DNA damage in embryos of the annual killifish Austrofundulus limnaeus

JT Wagner, JE Podrabsky - Journal of Experimental Zoology …, 2015 - Wiley Online Library
Free‐living aquatic embryos are often at risk of exposure to ultraviolet radiation (UV‐R).
Successful completion of embryonic development depends on efficient removal of DNA …

[HTML][HTML] UVB-induced cell death signaling is associated with G1-S progression and transcription inhibition in primary human fibroblasts

TG Ortolan, CFM Menck - PLoS One, 2013 - journals.plos.org
DNA damage induced by ultraviolet (UV) radiation can be removed by nucleotide excision
repair through two sub-pathways, one general (GGR) and the other specific for transcribed …

Sustained activation of p53 in confluent nucleotide excision repair-deficient cells resistant to ultraviolet-induced apoptosis

H Carvalho, TG Ortolan, T depaula, RA Leite… - dna repair, 2008 - Elsevier
p53 activation is one of the main signals after DNA damage, controlling cell cycle arrest,
DNA repair and apoptosis. We have previously shown that confluent nucleotide excision …

The Chinese or striped-back hamster

WP Feeney - The Laboratory Rabbit, Guinea Pig, Hamster, and …, 2012 - Elsevier
Publisher Summary Chinese hamsters are small rodents with a grayish black coat and a
black dorsal stripe. Adult animals weigh approximately 39–46 gm, and measure …

Resistance to ultraviolet-induced apoptosis in DNA repair deficient growth arrested human fibroblasts is not related to recovery from RNA transcription blockage

RMA da Costa, C Quayle, J de Fátima Jacysyn… - Mutation Research …, 2008 - Elsevier
The impact of ultraviolet (UV-C) photoproducts on apoptosis induction was investigated in
growth arrested (confluent) and proliferating human primary fibroblasts. Confluent fibroblasts …

[PDF][PDF] PERKEMBANGAN TEKNOLOGI SEL MAMALIA CHINESE HAMSTER OVARY (CHO) UNTUK PRODUKSI OBAT BERBASIS PROTEIN

A Santoso - BERITA BIOLOGI, 2019 - academia.edu
Sel hamster china (Chinese hamster ovary, CHO) dengan beberapa sel turunannya seperti
sel CHO-DXB11, CHO-K1, CHO-DG44 dan CHO-S adalah sel mamalia yang sangat sering …