The functional organization of axonal mRNA transport and translation
I Dalla Costa, CN Buchanan, MD Zdradzinski… - Nature Reviews …, 2021 - nature.com
Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …
localized mRNA translation to rapidly respond to different extracellular stimuli and …
Axonal mRNA transport and translation at a glance
Localization and translation of mRNAs within different subcellular domains provides an
important mechanism to spatially and temporally introduce new proteins in polarized cells …
important mechanism to spatially and temporally introduce new proteins in polarized cells …
Intranasal delivery of mesenchymal stem cell derived exosomes loaded with phosphatase and tensin homolog siRNA repairs complete spinal cord injury
Individuals with spinal cord injury (SCI) usually suffer from permanent neurological deficits,
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …
while spontaneous recovery and therapeutic efficacy are limited. Here, we demonstrate that …
SMN regulates axonal local translation via miR-183/mTOR pathway
Reduced expression of SMN protein causes spinal muscular atrophy (SMA), a
neurodegenerative disorder leading to motor neuron dysfunction and loss. However, the …
neurodegenerative disorder leading to motor neuron dysfunction and loss. However, the …
Evidence that the CAG repeat in the androgen receptor gene is associated with the age-related decline in serum androgen levels in men
K Krithivas, SM Yurgalevitch, BA Mohr… - Journal of …, 1999 - joe.bioscientifica.com
The presence of activin A and its effects have previously been documented in the adrenal
gland, particularly in the human fetal adrenal gland and the rat adrenal gland. The primary …
gland, particularly in the human fetal adrenal gland and the rat adrenal gland. The primary …
miR-182 regulates Slit2-mediated axon guidance by modulating the local translation of a specific mRNA
During brain wiring, cue-induced axon behaviors such as directional steering and branching
are aided by localized mRNA translation. Different guidance cues elicit translation of subsets …
are aided by localized mRNA translation. Different guidance cues elicit translation of subsets …
Specific mechanisms of translation initiation in higher eukaryotes: the eIF4G2 story
ED Shestakova, VV Smirnova, IN Shatsky, IM Terenin - Rna, 2023 - rnajournal.cshlp.org
The eukaryotic initiation factor 4G2 (eIF4G2, DAP5, Nat1, p97) was discovered in 1997. Over
the past two decades, dozens of papers have presented contradictory data on eIF4G2 …
the past two decades, dozens of papers have presented contradictory data on eIF4G2 …
Local translation across neural development: a focus on radial glial cells, axons, and synaptogenesis
M Agrawal, K Welshhans - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
In the past two decades, significant progress has been made in our understanding of mRNA
localization and translation at distal sites in axons and dendrites. The existing literature …
localization and translation at distal sites in axons and dendrites. The existing literature …
mRNP assembly, axonal transport, and local translation in neurodegenerative diseases
The development, maturation, and maintenance of the mammalian nervous system rely on
complex spatiotemporal patterns of gene expression. In neurons, this is achieved by the …
complex spatiotemporal patterns of gene expression. In neurons, this is achieved by the …
Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism
S Hardy, E Kostantin, SJ Wang… - Proceedings of the …, 2019 - National Acad Sciences
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1,
PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the …
PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the …