Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis

D Thomas, P Radhakrishnan - Molecular cancer, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with high morbidity and
mortality worldwide. To date, limited therapeutic achievements targeting cell proliferation …

Pancreatic stellate cells: a starring role in normal and diseased pancreas

MV Apte, RC Pirola, JS Wilson - Frontiers in physiology, 2012 - frontiersin.org
While the morphology and function of cells of the exocrine and endocrine pancreas have
been studied over several centuries, one important cell type in the gland, the pancreatic …

[HTML][HTML] Pancreatic stellate cell: Pandora's box for pancreatic disease biology

RR Bynigeri, A Jakkampudi, R Jangala… - World journal of …, 2017 - ncbi.nlm.nih.gov
Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

R Ruze, J Song, X Yin, Y Chen, R Xu… - Signal transduction and …, 2023 - nature.com
Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields

S Lopez, N Hallali, Y Lalatonne, A Hillion… - Nanoscale …, 2022 - pubs.rsc.org
The destruction of cells using the mechanical activation of magnetic nanoparticles with low-
frequency magnetic fields constitutes a recent and interesting approach in cancer therapy …

[HTML][HTML] Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice

SM Swain, JMJ Romac, SR Vigna, RA Liddle - JCI insight, 2022 - ncbi.nlm.nih.gov
Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of
pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged …

Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop

DK Andersen, Å Andren-Sandberg, EJ Duell… - Pancreas, 2013 - journals.lww.com
A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK) and the National Cancer Institute (NCI) on ''Pancreatitis-Diabetes …

Phosphoinositide 3-kinase signaling pathway in pancreatic ductal adenocarcinoma progression, pathogenesis, and therapeutics

D Murthy, KS Attri, PK Singh - Frontiers in physiology, 2018 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized
by its sudden manifestation, rapid progression, poor prognosis, and limited therapeutic …

Autophagy: a key player in pancreatic cancer progression and a potential drug target

J Gillson, YS Abd El-Aziz, LYW Leck, PJ Jansson… - Cancers, 2022 - mdpi.com
Simple Summary With the mortality rate of pancreatic cancer predicted to rise over the
coming years, it is essential that effective treatment strategies are developed as soon as …

The role of pancreatic stellate cells in pancreatic cancer

JAG Moir, J Mann, SA White - Surgical oncology, 2015 - Elsevier
Background The prognosis of pancreatic cancer remains desperately poor, with little
progress made over the past 30 years despite the development of new combination …