Immune cell interactions in tuberculosis
JAL Flynn, J Chan - Cell, 2022 - cell.com
Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data
A Montemurro, V Schuster, HR Povlsen… - Communications …, 2021 - nature.com
Prediction of T-cell receptor (TCR) interactions with MHC-peptide complexes remains highly
challenging. This challenge is primarily due to three dominant factors: data accuracy, data …
challenging. This challenge is primarily due to three dominant factors: data accuracy, data …
Perspectives and Advances in the Understanding of Tuberculosis
RL Kinsella, DX Zhu, GA Harrison… - Annual Review of …, 2021 - annualreviews.org
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a
leading cause of death due to infection in humans. To more effectively combat this …
leading cause of death due to infection in humans. To more effectively combat this …
TCRMatch: predicting T-cell receptor specificity based on sequence similarity to previously characterized receptors
WD Chronister, A Crinklaw, S Mahajan, R Vita… - Frontiers in …, 2021 - frontiersin.org
The adaptive immune system in vertebrates has evolved to recognize non-self antigens,
such as proteins expressed by infectious agents and mutated cancer cells. T cells play an …
such as proteins expressed by infectious agents and mutated cancer cells. T cells play an …
On TCR binding predictors failing to generalize to unseen peptides
Several recent studies investigate TCR-peptide/-pMHC binding prediction using machine
learning or deep learning approaches. Many of these methods achieve impressive results …
learning or deep learning approaches. Many of these methods achieve impressive results …
[HTML][HTML] MAIT cell-directed therapy of Mycobacterium tuberculosis infection
Mucosal-associated invariant T (MAIT) cells are potential targets of vaccination and host-
directed therapeutics for tuberculosis, but the role of MAIT cells during Mycobacterium …
directed therapeutics for tuberculosis, but the role of MAIT cells during Mycobacterium …
NetTCR-2.1: Lessons and guidance on how to develop models for TCR specificity predictions
T cell receptors (TCR) define the specificity of T cells and are responsible for their interaction
with peptide antigen targets presented in complex with major histocompatibility complex …
with peptide antigen targets presented in complex with major histocompatibility complex …
Augmentation of the riboflavin-biosynthetic pathway enhances mucosa-associated invariant T (MAIT) cell activation and diminishes Mycobacterium tuberculosis …
Mucosa-associated invariant T (MAIT) cells play a critical role in antimicrobial defense.
Despite increased understanding of their mycobacterial ligands and the clinical association …
Despite increased understanding of their mycobacterial ligands and the clinical association …
Identification of distinct immune cell subsets associated with asymptomatic infection, disease severity, and viral persistence in COVID-19 patients
X Wang, H Bai, J Ma, H Qin, Q Zeng, F Hu… - Frontiers in …, 2022 - frontiersin.org
The cell-mediated protective and pathogenic immune responses to SARS-CoV-2 infection
remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that …
remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that …
Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive
EW Meermeier, CL Zheng, JG Tran, S Soma… - Communications …, 2022 - nature.com
Abstract Mucosal-associated Invariant T (MAIT) cells are an innate-like T cell subset that
recognize a broad array of microbial pathogens, including respiratory pathogens. Here we …
recognize a broad array of microbial pathogens, including respiratory pathogens. Here we …