Resolving conflict of interest The Joint Task Force on Practice Parameters (JTFPP) is
committed to ensuring that all guidelines are based on the best scientific evidence at the …

Background For most physicians, quantification of drug-specific immunoglobulin E (drug-
sIgE) antibodies constitutes the primary in vitro measure to document immediate drug …

Background: Diagnosis of immediate drug hypersensitivity reactions (IDHRs) is based upon
history taking, skin prick or intradermal tests and quantification of specific immunoglobulin E …

Background The diagnosis of hypersensitivity reactions (HSR) to platins is based on the
characterization of the reaction and the results of skin testing. Platins can be irritants when …

Background Although ibuprofen and other arylpropionic acid derivatives (AP s) are the most
common medicines involved in hypersensitivity drug reactions (HDR s) to NSAID s, no …

Challenges in in vitro allergy diagnostics lie in the development of accessible and reliable
assays allowing identification of all offending allergens and cross-reactive structures. Flow …

Background: Nonsteroidal anti-inflammatory drugs (NSAIDS) are among the most common
causes of drug hypersensitivity (HS) reactions. The diagnosis is based on a careful clinical …

Background The aim of this study was to verify the validity of clinical history and oral
provocation challenges of patients with NSAID hypersensitivity and to identify safe …

Basophilic granulocytes, containing and releasing histamine after a specific allergy
stimulation, are directly involved in IgE-mediated allergic reactions. CD63 is a …

Challenges in in vitro immediate drug hypersensitivity reaction (DHR) diagnosis lie in the
development and validation of reliable assays enabling safe and correct identification of all …