Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …

The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …

There are numerous examples in psychology and other disciplines of the enduring effects of
early experience on neural function. In this article, we review the emerging evidence for …

This paper provides a review of the design and analysis of genetic association studies. In
case control studies, the different contingency tables and their relationships to the …

The study of inherited monogenic diseases has contributed greatly to our mechanistic
understanding of pathogenic mutations and gene regulation, and to the development of …

OBJECTIVE: Child and adolescent psychiatry is rife with examples of the sustained effects of
early experience on brain function. The study of behavioral genetics provides evidence for a …

Pref-1 is an EGF repeat-containing transmembrane protein that produces a biologically
active soluble form by TACE-mediated cleavage. Although Pref-1 inhibition of adipogenesis …

Uniparental disomy (UPD) refers to the situation in which both homologues of a
chromosomal region/segment have originated from only one parent. This can involve the …

Little is known about epigenetic mechanisms in birds with the exception of the phenomenon
of dosage compensation of sex chromosomes, although such mechanisms could be …

The nucleus is an ordered three-dimensional entity, and organization of the genome within
the nuclear space might have implications for orchestrating gene expression. Recent …