The great escape: tumour cell plasticity in resistance to targeted therapy
S Boumahdi, FJ de Sauvage - Nature reviews Drug discovery, 2020 - nature.com
The success of targeted therapies in cancer treatment has been impeded by various
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …
mechanisms of resistance. Besides the acquisition of resistance-conferring genetic …
Emerging role of tumor cell plasticity in modifying therapeutic response
Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …
have proposed that acquisition of resistance may result from genetic mutations. However …
[HTML][HTML] Battling chemoresistance in cancer: root causes and strategies to uproot them
With nearly 10 million deaths, cancer is the leading cause of mortality worldwide. Along with
major key parameters that control cancer treatment management, such as diagnosis …
major key parameters that control cancer treatment management, such as diagnosis …
Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance
H Lin, Y Wang, P Wang, F Long, T Wang - Molecular cancer, 2022 - Springer
The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to
recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of …
recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of …
Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance
H Easwaran, HC Tsai, SB Baylin - Molecular cell, 2014 - cell.com
The existence of subpopulations of cells in cancers with increased tumor-initiating capacities
and self-renewal potential, often termed" cancer stem cells," is a much discussed and key …
and self-renewal potential, often termed" cancer stem cells," is a much discussed and key …
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
Y Sun, J Campisi, C Higano, TM Beer, P Porter… - Nature medicine, 2012 - nature.com
Acquired resistance to anticancer treatments is a substantial barrier to reducing the
morbidity and mortality that is attributable to malignant tumors. Components of tissue …
morbidity and mortality that is attributable to malignant tumors. Components of tissue …
[HTML][HTML] A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
SV Sharma, DY Lee, B Li, MP Quinlan, F Takahashi… - Cell, 2010 - cell.com
Accumulating evidence implicates heterogeneity within cancer cell populations in the
response to stressful exposures, including drug treatments. While modeling the acute …
response to stressful exposures, including drug treatments. While modeling the acute …
Cancer chemotherapy
DL Gustafson, RL Page - Withrow and MacEwen's small animal …, 2013 - books.google.com
The use of chemical elixirs for the treatment of cancer can be traced through the medicinal
customs and practices of a number of cultures. 1 The modern use of pharmacologic agents …
customs and practices of a number of cultures. 1 The modern use of pharmacologic agents …
Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition
Understanding the emerging models of adaptive resistance is key to overcoming cancer
chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo …
chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo …
[HTML][HTML] Multidrug resistance associated proteins in multidrug resistance
Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …
named ATP-binding cassette (ABC) transporters. These ABC transporters together form the …