Appearance of pathogenic bacteria resistant to most, if not all, known antibiotics is currently
one of the most significant medical problems. Therefore, development of novel antibacterial …

Holins form pores in the cytoplasmic membranes of bacteria for the primary purpose of
releasing endolysins that hydrolyze the cell wall and induce cell death. Holins are encoded …

When phages infect bacteria cultured in the presence of sublethal doses of antibiotics, the
sizes of the phage plaques are significantly increased. This phenomenon is known as …

In the noisy cellular environment, gene products are subject to inherent random fluctuations
in copy numbers over time. How cells ensure precision in the timing of key intracellular …

How exponentially growing cells maintain size homeostasis is an important fundamental
problem. Recent single-cell studies in prokaryotes have uncovered the adder principle …

Viruses are differentiated from other mobile genetic elements by the encapsidation of their
genomes during some stage of their life cycles. It is during their infection of bacteria that …

Stochastic protein accumulation up to some concentration threshold sets the timing of many
cellular physiological processes. Here we obtain the exact distribution of first threshold …

Timing is essential for many cellular processes, from cellular responses to external stimuli to
the cell cycle and circadian clocks. Many of these processes are based on gene expression …

How the noisy expression of regulatory proteins affects timing of intracellular events is an
intriguing fundamental problem that influences diverse cellular processes. Here we use the …

Quantifying viral traits—including the adsorption rate, burst size, and latent period—is critical
to characterize viral infection dynamics and develop predictive models of viral impacts …