We review the evolution and structure of members of the transforming growth factor β (TGF-
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …

Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …

In the last 10 years, a large family of secreted signaling molecules has been discovered that
appear to mediate many key events in normal growth and development. The family is known …

The morbidity associated with autogenous bone graft harvest and the recent concern
regarding the transmission of live virus through use of allografts, have been the impetus for …

The implantation of bone morphogenetic protein (BMP) into muscular tissues induces
ectopic bone formation at the site of implantation. To investigate the mechanism underlying …

In the past thirty years, a number of biomaterials have shown the ability to induce bone
formation when implanted at heterotopic sites, an ability known as osteoinduction. Such …

Skeletal homeostasis is determined by systemic hormones and local factors. Bone
morphogenetic proteins (BMP) are unique because they induce the differentiation of …

Morphogenesis is the developmental cascade of pattern formation and body plan
establishment, culminating in the adult form. It has formed the basis for the emerging …

Osteoblasts arise from common progenitors with chondrocytes, muscle and adipocytes, and
various hormones and local factors regulate their differentiation. We review here regulation …

The combined application of molecular, biochemical, histochemical, and ultrastructural
approaches has defined a temporal sequence of gene expression associated with …