SNPs in genes encoding G proteins in pharmacogenetics

S Klenke, W Siffert - Pharmacogenomics, 2011 - Future Medicine
Heterotrimeric guanine-binding proteins (G proteins) transmit signals from the cell surface to
intracellular signal cascades and are involved in various physiological and …

The Effects of Dobutamine in Septic Shock: An Updated Narrative Review of Clinical and Experimental Studies

A Dubin, M Mugno - Medicina, 2024 - mdpi.com
The key objective in the hemodynamic treatment of septic shock is the optimization of tissue
perfusion and oxygenation. This is usually achieved by the utilization of fluids, vasopressors …

Pharmacogenomic characterization in bipolar spectrum disorders

S Fortinguerra, V Sorrenti, P Giusti, M Zusso, A Buriani - Pharmaceutics, 2019 - mdpi.com
The holistic approach of personalized medicine, merging clinical and molecular
characteristics to tailor the diagnostic and therapeutic path to each individual, is steadily …

Pharmacogenetics may explain part of the interindividual variability of dobutamine pharmacodynamics in neonates

M Hallik, H Soeorg, T Kahre… - British Journal of …, 2022 - Wiley Online Library
Aims To determine whether the known single nucleotide polymorphisms in adrenoreceptor
associated genes affect the haemodynamic response to dobutamine in critically ill neonates …

A review of potential pharmacogenetic effects on catecholamine responses

M Ounissi, A Benkirane, E Dempsey… - Drug Metabolism …, 2015 - Taylor & Francis
Considerably, variability in the clinical response to inotropic agents is observed and could
be explained partially by the genetic variants, such as single-nucleotide polymorphism …

GNAS1 基因T393C 单核苷酸多态性与非瓣膜性房颤的相关性

李虹, 胡兆霆, 谭珍妮, 侯庆臻, 彭健 - 南方医科大学学报, 2013 - cqvip.com
目的分析中国汉族人群Gs 蛋白a 亚基基因(GNAS1) T393C 单核苷酸多态性(SSV)
与非瓣膜性房颤是否存在相关陛. 方法分别选取非瓣膜性房颤患者90 例及正常对照90 例 …

GNAS1 基因T393C 多态性与特发性室性心律失常的相关分析

谭珍妮, 赖文岩, 邓伟, 孙少喜, 罗苑苑, 李蘅, 彭健 - 山东医药, 2010 - cqvip.com
目的分析Gs 蛋白α 亚基基因(GNAS1) T393C 单核苷酸多态性(SNP) 与特发性室性心律失常的
相关性. 方法分别选取特发性室性心律失常患者165 例及健康对照162 例, 采用PCR-RFLP …

Influence of 825 C> T polymorphism of G protein β subunit gene (GNB3) on hemodynamic response during dobutamine stress echocardiography

A Banaś, E Płońska, B Larysz, M Kurzawski… - Pharmacological …, 2012 - Springer
There is a wide interpersonal difference to dobutamine response during dobutamine stress
echocardiography (DSE). The aim of this study was to determine an association between …

Effect of the ADRB1 1165C>G and 145A>G polymorphisms on hemodynamic response during dobutamine stress echocardiography

A Banaś, E Płońska, M Kurzawski, W Gornik… - European journal of …, 2011 - Springer
Purpose The aim of this study was to determine an association between the ADRB1 1165C>
G and 145A> G polymorphisms and hemodynamic response [heart rate (HR), systolic (SBP) …

Influence of the 393T> C polymorphism of the GNAS1 gene on the intensity of opiate withdrawal

HS Bachmann, B Lieb, U Bonnet, M Specka… - …, 2011 - thieme-connect.com
There are high interindividual differences regarding the intensity of withdrawal symptoms. in
opiate addicts. This study was carried out in order to test whether the intensity of withdrawal …