Lipids play important roles in energy metabolism along with diverse aspects of biological
membrane structure, signaling and other functions. Perturbations of lipid metabolism are …

Sepsis-associated acute kidney injury (SA-AKI) is common in patients with severe sepsis,
and has a high incidence rate and high mortality rate in ICU patients. Most patients progress …

Patients admitted to the intensive care unit (ICU) are in need of continuous organ
replacement strategies and specialized care, for example because of neurological …

Sepsis is a systemic inflammatory response syndrome caused by infection, following with
acute injury to multiple organs. Sepsis-induced acute kidney injury (AKI) is currently …

Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Many
lines of evidence suggest that the disturbances in circadian rhythm are responsible for the …

Circadian rhythm perturbations can impact the evolution of different conditions, including
autoimmune diseases. This narrative review summarizes the current understanding of …

Circadian disruption is involved in the progress of sepsis-induced cardiomyopathy (SICM),
one of the leading causes of death in sepsis. The molecular mechanism remains …

Background The role of BMAL1 in various diseases remains unclear, particularly its impact
on sepsis-induced acute kidney injury (AKI). This study aims to investigate the role of BMAL1 …

The Earth's 24-h planetary rotation, with predictable light and heat cycles, has driven
profound evolutionary adaptation, with prominent impacts on physiological mechanisms …

Background Intervertebral disc (IVD) is a highly rhythmic tissue, which experiences a diurnal
cycle of high/low mechanical loading via the changes of activity/rest phase. There are signs …