The epigenetic link between polyphenols, aging and age-related diseases

I Arora, M Sharma, LY Sun, TO Tollefsbol - Genes, 2020 - mdpi.com
Aging is a complex process mainly categorized by a decline in tissue, cells and organ
function and an increased risk of mortality. Recent studies have provided evidence that …

Dietary antioxidants remodel DNA methylation patterns in chronic disease

M Beetch, S Harandi‐Zadeh, K Shen… - British journal of …, 2020 - Wiley Online Library
Chronic diseases account for over 60% of all deaths worldwide according to the World
Health Organization reports. Majority of cases are triggered by environmental exposures that …

Dietary phytoestrogens and their metabolites as epigenetic modulators with impact on human health

VS Ionescu, A Popa, A Alexandru, E Manole, M Neagu… - Antioxidants, 2021 - mdpi.com
The impact of dietary phytoestrogens on human health has been a topic of continuous
debate since their discovery. Nowadays, based on their presumptive beneficial effects, the …

Differential methylation and acetylation as the epigenetic basis of resveratrol's anticancer activity

M Farhan, MF Ullah, M Faisal, AA Farooqi… - Medicines, 2019 - mdpi.com
Numerous studies support the potent anticancer activity of resveratrol and its regulation of
key oncogenic signaling pathways. Additionally, the activation of sirtuin 1, a deacetylase, by …

Evidence for multilevel chemopreventive activities of natural phenols from functional genomic studies of curcumin, resveratrol, genistein, quercetin, and luteolin

L Huminiecki - International Journal of Molecular Sciences, 2022 - mdpi.com
Herein, I present an updated and contextualized literature review of functional genomic
studies of natural phenols in the context of cancer. I suggest multilevel chemopreventive and …

DNA methylation landscape of triple-negative ductal carcinoma in situ (DCIS) progressing to the invasive stage in canine breast cancer

M Beetch, S Harandi-Zadeh, T Yang, C Boycott… - Scientific reports, 2020 - nature.com
Triple-negative breast cancer (TNBC) is a subtype of breast cancer unresponsive to
traditional receptor-targeted treatments, leading to a disproportionate number of deaths …

[HTML][HTML] Differential Biological Effects of Trifolium pratense Extracts—In Vitro Studies on Breast Cancer Models

L Albulescu, A Suciu, M Neagu, C Tanase, S Pop - Antioxidants, 2024 - mdpi.com
The increasing popularity of herbal supplements emphasizes the need of scientific data
regarding their health benefits and possible toxicological concerns. The complexity of …

Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats

MA Tello‐Palencia, T Yang, O Sularz… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope Polyphenols from the phytoestrogen group, including pterostilbene (PTS), are known
for their antioxidant, anti‐inflammatory, and anti‐cancer effects. In recent reports …

Next generation sequencing of RNA reveals novel targets of resveratrol with possible implications for Canavan disease

M Dembic, HS Andersen, J Bastin, TK Doktor… - Molecular Genetics and …, 2019 - Elsevier
Resveratrol (RSV) is a small compound first identified as an activator of sirtuin 1 (SIRT1), a
key factor in mediating the effects of caloric restriction. Since then, RSV received great …

[HTML][HTML] Hydroxytyrosol decreases EDNRA expression through epigenetic modification in colorectal cancer cells

A del Saz-Lara, H Boughanem… - Pharmacological …, 2023 - Elsevier
The Mediterranean diet (MD) is one of the healthiest ones and is associated with a lower
incidence of cardiovascular and cerebrovascular diseases as well as cancer. Extra virgin …